BindingDB BDBM21397 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL267930::MLS000028615::SMR000058674::SPIPERONE::Spiroperidol::US9359372, Spiperone::[3H]-Spiroperidol::cid_5265

BDBM21397 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL267930::MLS000028615::SMR000058674::SPIPERONE::Spiroperidol::US9359372, Spiperone::[3H]-Spiroperidol::cid_5265

SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key InChIKey=DKGZKTPJOSAWFA-UHFFFAOYSA-N

Data 304 KI 17 IC50 3 Kd 1 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 21397

5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 17nMAssay Description:Displacement of [3H]spiperone from human recombinant 5HT1A receptor expressed in CHO cell membrane incubated for 1 hr by scintillation counting metho...More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 17.2nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 17.4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 25nMAssay Description:Binding affinity against native 5-HT1A-receptors from rat hippocampus using radioligand ([3H]8-hydroxy-2-(di-n-propylamino)-tetraline) binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 30nMAssay Description:Binding affinity of compound against 5-hydroxytryptamine 1A receptor binding site using radioligand [3H]8-OH-DPATMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 33.1nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 40nMAssay Description:Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a ra...More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 49nMAssay Description:Tested for binding affinity against 5-hydroxytryptamine 1A receptor from rat frontal cortical regions using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 58nMAssay Description:Binding affinity against rat 5-hydroxytryptamine 1A receptor in CHO cells.More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 60nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 61nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 63.1nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 115nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 158nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 209nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 411nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 427nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

Ki: 602nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue ...More data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL

PNG

BDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)

IC50: 123nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain membrane using [3H]8-OH-DPAT as a selective ligand.More data for this Ligand-Target Pair

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Filter my 323 hits

Targets 42▿
- D(2) dopamine receptor 81
- 5-hydroxytryptamine receptor 2A 29
- 5-hydroxytryptamine receptor 7 25
- 5-hydroxytryptamine receptor 2C 20
- D(3) dopamine receptor 19
- 5-hydroxytryptamine receptor 1A 19
- 5-hydroxytryptamine receptor 2B 17
- D(4) dopamine receptor 15
- Alpha-1A adrenergic receptor 14
- D(1A) dopamine receptor 11
- 5-hydroxytryptamine receptor 1B 6
- Serotonin 2 (5-HT2) receptor 6
- 5-hydroxytryptamine receptor 1D 6
- Alpha-2C adrenergic receptor 5
- Alpha-1B adrenergic receptor 5
- 5-hydroxytryptamine receptor 6 5
- Sigma non-opioid intracellular receptor 1 4
- Histamine H1 receptor 3
- 5-hydroxytryptamine receptor 5A 2
- Alpha-1D adrenergic receptor 2
- D(1B) dopamine receptor 2
- 5-hydroxytryptamine receptor 3A 2
- Muscarinic acetylcholine receptor M2 2
- 5-hydroxytryptamine receptor 1F 2
- 5-hydroxytryptamine receptor 1E 2
- D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor 2
- Alpha-2A adrenergic receptor 2
- Sodium-dependent serotonin transporter 1
- Sphingosine 1-phosphate receptor 3 1
- Solute carrier family 22 member 1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- 5-hydroxytryptamine receptor 5B 1
- Beta-casein 1
- Vesicular acetylcholine transporter 1
- 5-hydroxytryptamine 1D receptor 1
- Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 1
- HLA class I histocompatibility antigen, A alpha chain 1
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 1
- Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Bile salt export pump 1
- ...
Publications 50▿
- Neuropharmacology 33: 275-317 (1994) 25
- J Med Chem 39: 4602-7 (1996) 9
- J Med Chem 46: 2795-812 (2003) 8
- Eur J Pharmacol 291: 59-66 (1995) 8
- Br J Pharmacol 115: 622-8 (1995) 8
- NIDA Res Monogr 178: 440-66 (1998) 7
- J Med Chem 30: 1-12 (1987) 7
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- Nature 350: 610-4 (1991) 6
- J Pharmacol Exp Ther 272: 134-42 (1995) 6
- Bioorg Med Chem 24: 3671-9 (2016) 6
- J Pharmacol Exp Ther 268: 495-502 (1994) 6
- J Pharmacol Exp Ther 315: 109-17 (2005) 6
- Br J Pharmacol 130: 692-8 (2000) 5
- Neuropharmacology 36: 621-9 (1997) 5
- J Pharmacol Exp Ther 268: 1403-10 (1994) 5
- J Pharmacol Exp Ther 268: 337-52 (1994) 5
- J Pharmacol Exp Ther 257: 1253-63 (1991) 5
- Eur J Pharmacol 103: 197-204 (1984) 5
- Trends Pharmacol Sci 18: 104-7 (1997) 4
- J Med Chem 41: 5084-93 (1999) 4
- J Pharmacol Exp Ther 315: 1278-87 (2005) 4
- Neuropsychopharmacology 20: 612-27 (1999) 4
- J Med Chem 36: 2519-25 (1993) 4
- J Pharmacol Exp Ther 252: 1108-16 (1990) 4
- Eur J Pharmacol 347: 301-9 (1998) 4
- Psychopharmacology (Berl) 120: 365-8 (1995) 3
- US Patent US9359372 (2016) 3
- Naunyn Schmiedebergs Arch Pharmacol 361: 569-72 (2000) 3
- J Med Chem 62: 5132-5147 (2019) 3
- Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) 3
- Proc Natl Acad Sci U S A 89: 3630-4 (1992) 3
- Bioorg Med Chem 20: 4862-71 (2012) 3
- Proc Natl Acad Sci U S A 86: 9762-6 (1989) 3
- J Med Chem 60: 9905-9910 (2017) 3
- Synapse 15: 169-76 (1993) 3
- Life Sci 33: 2011-6 (1983) 3
- J Pharmacol Exp Ther 227: 592-9 (1983) 3
- J Pharmacol Exp Ther 241: 1092-8 (1987) 3
- J Med Chem 48: 694-709 (2005) 3
- J Med Chem 31: 1087-93 (1988) 3
- Eur J Pharmacol 146: 113-20 (1988) 2
- Bioorg Med Chem 21: 856-68 (2013) 2
- J Med Chem 35: 423-30 (1992) 2
- Life Sci 35: 1885-93 (1984) 2
- J Med Chem 38: 3415-44 (1995) 2
- Nature 347: 146-51 (1990) 2
- Life Sci 37: 1971-83 (1985) 2
- Chem Biol Drug Des 88: 599-607 (2016) 2
- Mol Pharmacol 12: 800-12 (1976) 2
- ...
Institutions 39▿
- University of Alberta 25
- University of Toronto 17
- Virginia Commonwealth University 16
- Mayo Clinic 12
- University of Pennsylvania 10
- TBA 9
- Roche Bioscience 9
- University Of Camerino 9
- Syntex Discovery Research 8
- Case Western Reserve University 8
- Sri International 7
- Florida A&M University 6
- Duke University 6
- Universit&Aagrove 6
- University of California 6
- Washington University 6
- Friedrich-Schiller-University Jena 5
- Institut De Recherches Servier 5
- Department of Veterans Affairs Medical Center 4
- University of North Carolina 4
- Acadia Pharmaceuticals 4
- Uppsala University 4
- Shenyang Pharmaceutical University 3
- Vernalis Research 3
- Shanghai Institute of Material Medica, Chinese Academy of Sciences 3
- Merrell Dow Research Institute 3
- Croissy-Sur-Seine Paris 3
- University Of Pennsylvania 3
- Synaptic Pharmaceutical 3
- Oregon Health Sciences University 3
- Friedrich-Alexander University 3
- Vanderbilt University 3
- Schering-Plough 2
- Smithkline Beecham Pharmaceuticals 2
- U. 109 2
- UniversitÉ 2
- Fudan University 2
- Novo Industri 2
- Chinese Academy Of Sciences 2
- ...
Affinity: 0 to 6.3E+4 nM▿
- Ki 304
- IC50 17
- Kd 3
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1